個(gè)人簡(jiǎn)介

    上海交通大學(xué)教授、博導(dǎo)，華南農(nóng)業(yè)大學(xué)生物智造創(chuàng)新研究院兼職院長(zhǎng)、教授，國(guó)家級(jí)青年人才，從事“AI+生物制造”研究，主持國(guó)家重點(diǎn)研發(fā)計(jì)劃(青年)、國(guó)家自然科學(xué)基金等項(xiàng)目，在Nature Biotechnology、Molecular Plant等國(guó)際專業(yè)期刊發(fā)表論文近30篇，申請(qǐng)專利近30項(xiàng)，完成近千萬(wàn)元產(chǎn)業(yè)轉(zhuǎn)化。同時(shí)作為（聯(lián)合）創(chuàng)始人連續(xù)創(chuàng)立了未米生物、堯唐生物、百格基因等多家行業(yè)領(lǐng)先科技企業(yè)，近3年完成融資超7億元（估值超20億），在農(nóng)業(yè)和醫(yī)學(xué)領(lǐng)域都獲得了重要進(jìn)展，重要成果包括：

1. 開發(fā)了我國(guó)目前唯一可用于體內(nèi)臨床的基因編輯Cas酶，轉(zhuǎn)化的臨床管線實(shí)現(xiàn)超10億元技術(shù)授權(quán)，治愈多名重癥患兒

2. 建立了全套自主基因編輯育種體系，申報(bào)多項(xiàng)農(nóng)業(yè)部基因編輯安全證書

3. 建成國(guó)際最大水稻基因編輯種質(zhì)庫(kù)，全基因覆蓋率超90%，分發(fā)種質(zhì)超15000份

研究興趣

1. 蛋白設(shè)計(jì)與進(jìn)化

2. AI驅(qū)動(dòng)的“端到端”育種體系開發(fā)與應(yīng)用

工作和教育經(jīng)歷

主持科研項(xiàng)目

1. 上海市科技興農(nóng)技術(shù)創(chuàng)新項(xiàng)目，K2023001，2023-2026，226萬(wàn)元，主持

2. 國(guó)家級(jí)青年拔尖人才，SQ2022QB08348，2023-2025，200萬(wàn)元，主持

3. 國(guó)家重點(diǎn)研發(fā)計(jì)劃(青年)，2021YFD1201300，水稻和玉米氮高效新種質(zhì)精準(zhǔn)創(chuàng)制與應(yīng)用，2022-2026，400萬(wàn)元，主持

4. 橫向科研項(xiàng)目，22H010104285，新型基因編輯工具的挖掘與進(jìn)化，2022-2024，100萬(wàn)元，主持

5. 國(guó)家自然科學(xué)基金面上項(xiàng)目，32070396，基于翻譯調(diào)控的水稻分子設(shè)計(jì)育種及其機(jī)制研究，2021-2024，58萬(wàn)元，主持

6. 浙江大學(xué)常州工業(yè)技術(shù)研究院合作基金，2017-2021，300萬(wàn)元，主持

7. 江蘇省常州市“龍城人才”計(jì)劃，水稻全基因組敲除突變體庫(kù)的創(chuàng)制，2017，200萬(wàn)元，主持

近幾年代表性論文(# first author, * corresponding author)

1. Wang D, Tan Z, Gao J, Zhang S, Shen J, & Lu, Y.*(2025)AI4Protein: transforming the future of protein design. SCIENCE CHINA Life Sciences. doi: 10.1007/s11427-024-2906-3.

2. Yao, Q., Shen, R., Shao, Y., Tian, Y., Han, P., Zhang, X., Zhu, J.K.*, & Lu, Y.* (2024). Efficient and multiplex gene upregulation in plants through CRISPR-Cas-mediated knockin of enhancers. Molecular Plant, 17(9), 1472-1483.

3. Tian, Y., Zhong, D., Shen, R., Tan, X., Zhu, C., Li, K., Yao, Q., Li, X., Zhang, X., Cao, X., Wang, P., Zhu, J.K.*, & Lu, Y.* (2024). Rapid and dynamic detection of endogenous proteins through in locus tagging in rice. Plant Communications, 101040.

4. Zhang, X., Song, M., Wang, Y., Yao, Q., Shen, R., Tian, Y.*, Lu, Y.*, & Zhu, J.K.* (2024). Programmable broad-spectrum resistance to bacterial blight using targeted insertion in rice. Cell Discovery, 10(1), 100.

5. Shen R, Yao Q, Tan X, Ren W, Zhong D, Zhang X, Li X, Dong C, Cao X, Tian Y, Zhu JK*, Lu Y.* (2024) In-locus gene silencing in plants using genome editing. New Phytologist. 243(6):2501-2511.

6. Zhong D, Pan H, Li K, Zhou Y, Zhao F, Ye L, Ruan S, Deng Q, Xu J, Lu Y.* (2024) Targeted A-to-T and A-to-C base replacement in maize using an optimized adenine base editor. Plant biotechnology journal, 22(3):541-543.

7. Liu, T., Zhang, X., Li, K., Yao, Q., Zhong, D., Deng, Q., Lu, Y.* (2023) Large-scale genome editing in plants: approaches, applications, and future perspectives, Current Opinion in Biotechnology, 79:102875

8. Shen, R., Yao, Q., Zhong, D., Zhang, X., Li, X., Cao, X., Dong, C., Tian, Y., Zhu, J-K and Lu, Y.* (2023) Targeted insertion of regulatory elements enables translational enhancement in rice. Frontiers in Plant Science, 14:1134209

9. Tian, Y., Zhong, D., Li, X., Shen, R., Han, H., Dai, Y., Yao, Q., Zhang, X., Deng, Q., Cao, X., Zhu, J. K., and Lu, Y.* (2022). High-throughput genome editing in rice with a virus-based surrogate system. Journal of integrative plant biology, 10.1111/jipb.13381

10. Tian, Y., Shen, R., Li, Z., Yao, Q., Zhang, X., Zhong, D., Tan, X., Song, M., Han, H., Zhu, J. K., and Lu, Y.* (2022). Efficient C-to-G editing in rice using an optimized base editor. Plant biotechnology journal, 20(7):1238–1240.

11. Lu, Y.*, Ronald, P.C., Han, B., Li, J. and Zhu, J.K. (2020). Rice Protein Tagging Project: A Call for International Collaborations on Genome-wide In-Locus Tagging of Rice Proteins. Molecular Plant 13(12):1663-1665.

12. Lu, Y.^#, Tian, Y.^#, Shen, R., Yao, Q., Wang, M., Chen, M., Dong, J., Zhang, T., Li, F., Lei, M. and Zhu, J.K.* (2020). Targeted, efficient sequence insertion and replacement in rice. Nature Biotechnology 38(12):1402-1407.

13. Lu, Y.*^#, Tian, Y.^#, Shen, R., Yao, Q., Zhong, D., Zhang, X., and Zhu, J.K.* (2021). Precise genome modification in tomato using an improved prime editing system. Plant biotechnology journal 19(3):415-417.

14. Lu, Y., Ye, X., Guo, R., Huang, J., Wang, W., Tang, J., Tan, L., Zhu, J.K., Chu, C., and Qian, Y.* (2017). Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System. Molecular Plant 10:1242-1245.

15. Lu, Y., and Zhu, J.K.* (2017). Precise Editing of a Target Base in the Rice Genome Using a Modified CRISPR/Cas9 System. Molecular Plant10:523-525.

16. Wang, M.^#, Lu, Y.^#, Botella, J.R., Mao, Y., Hua, K., and Zhu, J.K.* (2017). Gene Targeting by Homology-Directed Repair in Rice Using a Geminivirus-Based CRISPR/Cas9 System. Molecular Plant10:1007-1010.