連啟超 博士
教授、博士生導(dǎo)師
華南農(nóng)業(yè)大學(xué) 生命科學(xué)學(xué)院
聯(lián)系方式：qclian@scau.edu.cn
個(gè)人簡介
連啟超博士，華南農(nóng)業(yè)大學(xué)教授，博士生導(dǎo)師，課題組組長/PI，國家級(jí)青年人才項(xiàng)目獲得者，德國馬普學(xué)會(huì)伙伴研究組組長，洪堡學(xué)者。2019年7月，于復(fù)旦大學(xué)獲得生物信息學(xué)博士學(xué)位；2019年9月至2024年12月，在德國馬克斯普朗克植物育種研究所從事博士后研究；2025年1月入職華南農(nóng)業(yè)大學(xué)生命科學(xué)學(xué)院任教授。主要研究領(lǐng)域?yàn)樯镄畔W(xué)、計(jì)算基因組學(xué)與遺傳學(xué)、基因組變異和減數(shù)分裂重組多態(tài)性等。近年來，以第一作者和通訊作者（含共同）在Nature Genetics, Molecular Plant, Nature Communications (2022a, 2022b, 2025), Nucleic Acids Research等期刊上發(fā)表論文，以主要作者在Nature Plants, Nature Communications, Genome Biology, PNAS, Nucleic Acids Research等期刊上發(fā)表論文。擔(dān)任New Crops青年編委。
研究領(lǐng)域
整合利用生物信息學(xué)、計(jì)算基因組學(xué)與遺傳學(xué)、演化發(fā)育生物學(xué)以及高通量多維組學(xué)等技術(shù)手段，以作物大豆和模式植物擬南芥等為材料，系統(tǒng)探究基因組變異、減數(shù)分裂重組多態(tài)性及剖析大豆高產(chǎn)優(yōu)質(zhì)性狀和環(huán)境適應(yīng)性的遺傳基礎(chǔ)，為優(yōu)良品種遺傳改良、創(chuàng)制和基因組輔助設(shè)計(jì)育種提供理論基礎(chǔ)和指導(dǎo)。
課題組長期歡迎有志于從事上述研究的博士后、研究生、研究助理及本科生加盟！
主持和參加的科研項(xiàng)目
國家自然科學(xué)基金委項(xiàng)目（2026-2028，主持）
德國馬普學(xué)會(huì)伙伴研究組項(xiàng)目（2025-2030，主持）
華南農(nóng)業(yè)大學(xué)人才引進(jìn)項(xiàng)目（2025-2028，主持）
國家級(jí)青年人才項(xiàng)目（2025-2027，主持）
德國洪堡基金會(huì)研究項(xiàng)目（2021-2022，主持）
國家自然科學(xué)基金委項(xiàng)目（2018-2021，參與）
國家自然科學(xué)基金委項(xiàng)目（2016-2019，參與）
國家自然科學(xué)基金委重大研究計(jì)劃（2016-2018，參與）
發(fā)表論文(#為第一作者)
Xu, W.#, Lian, Q.#, Li, M., Copenhaver, G.P., and Wang, Y. (2025). The regulatory mechanisms controlling meiotic cross-over patterning in plants. Biochemical Society Transactions, 10.1042/BST20253025.
Lian, Q.*, Jiao, W.B.*, and Wang, Y.* (2025). Designing Better Crops with Phased Pangenomes. Molecular Plant, 10.1016/j.molp.2025.08.014.
Jing, J.#, Lian, Q.#, Durand, S., and Mercier, R., 2025. Maximizing meiotic crossover rate reveals the map of Crossover Potential. Nature Communications, 16(1), p.5306.
Lian, Q., Huettel, B., Walkemeier, B., Mayjonade, B., Lopez-Roques, C., Gil, L., Roux, F., Schneeberger, K. and Mercier, R., 2024. A pan-genome of 69 Arabidopsis thaliana accessions reveals a conserved genome structure throughout the global species range. Nature Genetics, pp.1-10. (Featured Article，高被引)
Lian, Q.and Mercier, R., 2024. Constants and variations in 69 diverse genomes of Arabidopsis thaliana. Nature Genetics, 56(5), pp.748-749.
Lian, Q., Maestroni, L., Gaudin, M., Llorente, B. and Mercier, R., 2023. Meiotic recombination is confirmed to be unusually high in the fission yeast Schizosaccharomyces pombe. iScience, 26(9).
Lian, Q., Solier, V., Walkemeier, B., Durand, S., Huettel, B., Schneeberger, K. and Mercier, R., 2022. The megabase-scale crossover landscape is largely independent of sequence divergence. Nature Communications, 13(1), p.3828.
Durand, S.#, Lian, Q.#, Jing, J.#, Ernst, M., Grelon, M., Zwicker, D. and Mercier, R., 2022. Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage. Nature Communications, 13(1), p.5999.
Lian, Q., Chen, Y., Chang, F., Fu, Y. and Qi, J., 2022. inGAP-family: accurate detection of meiotic recombination loci and causal mutations by filtering out artificial variants due to genome complexities. Genomics, Proteomics and Bioinformatics, 20(3), pp.524-535.
Liu, J.#, Lian, Q.#, Chen, Y. and Qi, J., 2019. Amino acid based de Bruijn graph algorithm for identifying complete coding genes from metagenomic and metatranscriptomic short reads. Nucleic Acids Research, 47(5), pp.e30-e30. （2019年度“中國生物信息學(xué)十大算法和工具”）
Capilla-Pérez, L., Solier, V., Gilbault, E., Lian, Q., Goel, M., Huettel, B., Keurentjes, J.J., Loudet, O. and Mercier, R., 2024. Enhanced recombination empowers the detection and mapping of Quantitative Trait Loci. Communications Biology, 7(1), p.829.
Fernandes, J.B., Naish, M., Lian, Q., Burns, R., Tock, A.J., Rabanal, F.A., Wlodzimierz, P., Habring, A., Nicholas, R.E., Weigel, D. and Mercier, R., 2024. Structural variation and DNA methylation shape the centromere-proximal meiotic crossover landscape in Arabidopsis. Genome Biology, 25(1), p.30.
Wang, T., Wang, H., Lian, Q., Jia, Q., You, C., Copenhaver, G.P., Wang, C. and Wang, Y., 2023. HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation. Proceedings of the National Academy of Sciences of the United States of America, 120(52), p.e2310542120.
Vrielynck, N.#, Peuch, M.#, Durand, S., Lian, Q., Chambon, A., Hurel, A., Guérin, J., Guérois, R., Mercier, R., Grelon, M. and Mézard, C., 2023. SCEP1 and SCEP2 are two new components of the synaptonemal complex central element. Nature Plants, 9(12), pp.2016-2030.
Singh, D.K., Lian, Q., Durand, S., Fernandes, J.B., Chambon, A., Hurel, A., Walkemeier, B., Solier, V., Kumar, R. and Mercier, R., 2023. HEIP1 is required for efficient meiotic crossover implementation and is conserved from plants to humans. Proceedings of the National Academy of Sciences of the United States of America, 120(23), p.e2221746120.
Vernet, A.#, Meynard, D.#, Lian, Q., Mieulet, D., Gibert, O., Bissah, M., Rivallan, R., Autran, D., Leblanc, O., Meunier, A.C. et al., 2022. High-frequency synthetic apomixis in hybrid rice. Nature Communications, 13(1), p.7963.
Capilla-Pérez, L., Durand, S., Hurel, A., Lian, Q., Chambon, A., Taochy, C., Solier, V., Grelon, M. and Mercier, R., 2021. The synaptonemal complex imposes crossover interference and heterochiasmy in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America, 118(12), p.e2023613118.
Lv, Z.#, Zhao, M.#, Wang, W.#, Wang, Q., Huang, M., Li, C., Lian, Q., Xia, J., Qi, J., Xiang, C., Tang, H. et al., 2021. Changing Gly311 to an acidic amino acid in the MATE family protein DTX6 enhances Arabidopsis resistance to the dihydropyridine herbicides. Molecular Plant, 14(12), pp.2115-2125.
Fang, X.#, Han, Y.#, Liu, M.#, Jiang, J., Li, X., Lian, Q., Xie, X., Huang, Y., Ma, Q., Nian, H., Qi, J. et al., 2021. Modulation of evening complex activity enables north-to-south adaptation of soybean. Science China Life Sciences, 64, pp.179-195.
Wang, H.#, Xu, W.#, Sun, Y., Lian, Q., Wang, C., Yu, C., He, C., Wang, J., Ma, H., Copenhaver, G.P. and Wang, Y., 2020. The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants. PLoS Genetics, 16(6), p.e1008849.
Sun, J., Tian, Y., Lian, Q. and Liu, J.X., 2020. Mutation of DELAYED GREENING1 impairs chloroplast RNA editing at elevated ambient temperature in Arabidopsis. Journal of Genetics and Genomics, 47(4), pp.201-212.
Gu, Z., Pan, W., Chen, W., Lian, Q., Wu, Q., Lv, Z., Cheng, X. and Ge, X., 2019. New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage. BMC Plant Biology, 19, pp.1-18.
