姓名：林如琴
職稱：首聘副教授
性別：女
所屬單位：生物化學(xué)系
E-mail: linruqin@scau.edu.cn
辦公室：生科院南樓305
個(gè)人簡介：
2020年6月畢業(yè)于華南農(nóng)業(yè)大學(xué)生物化學(xué)與分子生物學(xué)專業(yè)，獲理學(xué)博士學(xué)位。2020年6月至2022年6月在華南農(nóng)業(yè)大學(xué)進(jìn)行博士后研究。2022年7月入職華南農(nóng)業(yè)大學(xué)生命科學(xué)學(xué)院真菌毒素研究團(tuán)隊(duì)，主要從事真菌毒素毒理及致病機(jī)制研究。
研究方向
真菌毒素的腸道毒理機(jī)制研究
主持及參與的科研課題
1. 國家自然科學(xué)基金青年項(xiàng)目，主持
2. 中國博士后科學(xué)基金，主持
3. 國家自然科學(xué)基金面上項(xiàng)目，參與
4. 嶺南現(xiàn)代農(nóng)業(yè)科學(xué)與技術(shù)廣東省實(shí)驗(yàn)室科研項(xiàng)目，參與
科研獎(jiǎng)勵(lì)
第十二屆大北農(nóng)科技獎(jiǎng)創(chuàng)新獎(jiǎng)，飼料中常見霉菌毒素的分子毒理與生物防控. 鄧詣群，蔣珺，文繼開，母培強(qiáng)，汪玲玲，吳駿，林如琴，陳慶梅，鄧鳳如，孫峪.
發(fā)表論文
1.Lin R, Li D, Xu Y, Wei M, Chen Q, Deng Y, Wen J. Chronic cereulide exposure causes intestinal inflammation and gut microbiota dysbiosis in mice. Environmental Pollution. 2021, 288:117814.
2.Lin R#, Xiao M#, Cao S#, Sun Y#, Zhao L, Mao X, Chen P, Tong X, Ou Z, Zhu H, Men D*, Li X*, Deng Y*, Zhang X*, Wen J*. Distinct gut microbiota and health outcomes in asymptomatic infection, viral nucleic acid test re-positive and convalescent COVID-19 cases. mLife. 2022, doi: 10.1002/mlf2.12022.
3.Lin R, Sun Y, Mu P, Zheng T, Mu H, Deng F, Deng Y*, Wen J*. Lactobacillus rhamnosus GG supplementation modulates the gut microbiota to promote butyrate production, protecting against deoxynivalenol exposure in nude mice. Biochemical Pharmacology. 2020,175:113868.
4.Lin R, Sun Y, Ye W, Zheng T, Wen J*, Deng Y*. T-2 toxin inhibits the production of mucin via activating the IRE1/XBP1 pathway. Toxicology. 2019, 424:152230.
5.Li D #,Lin R#, Xu Y, Chen Q, Deng F, Deng Y*, Wen J*. Cereulide Exposure Caused Cytopathogenic Damages of Liver and Kidney in Mice. International Journal of Molecular Sciences. 2021, 24;22(17):9148.
6.Sun Y, Jiang J, Mu P, Lin R, Wen J*, Deng Y*. Toxicokinetics and metabolism of deoxynivalenol in animals and humans. Archives of toxicology. 2022，96(10):2639-2654.
7.Sun Y, Zhang M, Ou Z, Meng Y, Chen Y, Lin R, Hashim J, Hashim Z, Wieslander G, Chen Q, Norback D, Fu X.Indoor microbiome, microbial and plant metabolites, chemical compounds and asthma symptoms in junior high school students-a multi-center association study in Malaysia. European Respiratory Journal. 2022,2200260.
8.Lin R, Zhang Y, Long B, Li Y, Wu Y, Duan S, Zhu B, Wu X*, Fan H*. Oral Immunization with Recombinant Lactobacillus acidophilus Expressing espA-Tir-M Confers Protection against Enterohemorrhagic Escherichia coli O157:H7 Challenge in Mice. Frontiers in Microbiology. 2017, 8:417.
9.Lin R, Zhu B, Zhang Y, Bai Y, Zhi F, Long B, Li Y, Wu Y, Wu X*, Fan H*. Intranasal immunization with novel EspA-Tir-M fusion protein induces protective immunity against enterohemorrhagic Escherichia coli O157:H7 challenge in mice. Microbial Pathogenesis. 2017, 105:19-24.
10.Ye W, Lin R, Chen X, Chen J, Chen R, Xie X, Deng Y*, Wen J*. T-2 toxin upregulates the expression of human cytochrome P450 1A1 (CYP1A1) by enhancing NRF1 and Sp1 interaction. Toxicology Letters. 2019,15;315:77-86.
授權(quán)發(fā)明專利
范宏英，林如琴，吳嫻波，龍北國，張益多. 一種EHEC O157:H7重組嗜酸乳桿菌載體疫苗及其制備方法和應(yīng)用.
