文繼開

      現(xiàn)任華南農(nóng)業(yè)大學(xué)生命科學(xué)學(xué)院教授（博士生導(dǎo)師）、生化與分子生物學(xué)系系主任、廣東省農(nóng)業(yè)生物蛋白質(zhì)功能與調(diào)控重點(diǎn)實(shí)驗(yàn)室PI。
      1999年湖北大學(xué)學(xué)士，2002年中國(guó)科學(xué)院武漢病毒研究所碩士，2010年英國(guó)伯明翰大學(xué)博士。長(zhǎng)期從事基因與RNA表達(dá)調(diào)控方面的研究，在已有RNA調(diào)控的研究基礎(chǔ)上，致力于研究霉菌毒素對(duì)動(dòng)物細(xì)胞的分子毒理和表達(dá)調(diào)控的影響，重點(diǎn)關(guān)注代表性霉菌毒素在動(dòng)物體內(nèi)或細(xì)胞中的毒理效應(yīng)機(jī)制、表達(dá)調(diào)控影響和重要RNA關(guān)聯(lián)性事件的研究。主持國(guó)家自然科學(xué)基金面上項(xiàng)目、十三五重點(diǎn)研發(fā)子課題、廣東省自然科學(xué)基金項(xiàng)目等。目前已經(jīng)發(fā)表相關(guān)研究論文27篇，SCI收錄26篇。

2014.01- 華南農(nóng)業(yè)大學(xué)生命科學(xué)學(xué)院 教授

2010.06-2013.12 伯明翰大學(xué)生物系 Research Fellow 

2009.11-2010.05 伯明翰大學(xué)生物系 Research Assistant 

2002.08-2005.10 中國(guó)科學(xué)院武漢病毒研究所 助理研究員

1.微生物毒素在動(dòng)物細(xì)胞內(nèi)的毒理效應(yīng)機(jī)制
      以動(dòng)物細(xì)胞和小鼠為模型，研究微生物毒素進(jìn)入動(dòng)物體內(nèi)后引起的應(yīng)激性信號(hào)通路和多種損傷、毒理機(jī)制的關(guān)聯(lián)性規(guī)律，主要闡釋肝腸腎細(xì)胞的ROS，Oxidative stress，ER stress信號(hào)通路與表型的聯(lián)系。
2.動(dòng)物細(xì)胞內(nèi)的RNA生物學(xué)事件
      以真核細(xì)胞為模型，研究外源化合物刺激下，不同RNA分子的豐度、半衰期變化機(jī)制性揭示，包括對(duì)Splicing、翻譯效率、mRNA降解的影響。

廣東省生化與分子生物學(xué)會(huì) 常務(wù)理事

廣東省生物物理學(xué)會(huì) 常務(wù)理事

廣東省藥理學(xué)會(huì)藥物代謝專業(yè)委員會(huì) 常務(wù)委員

國(guó)家自然科學(xué)基金面上項(xiàng)目；國(guó)家自然科學(xué)基金廣東聯(lián)合基金（參與）；十三五重點(diǎn)研發(fā)子課題項(xiàng)目；廣東省教育廳重點(diǎn)項(xiàng)目；廣東省自然科學(xué)基金自由申請(qǐng)項(xiàng)目。

^#:同等貢獻(xiàn)作者；*共同通訊作者
1.Yu Sun^#, Jikai Wen^#, Ruohong Chen, and Yiqun Deng*. Variable protein homeostasis in housekeeping and non-housekeeping pathways under mycotoxins stress. Scientific Reports. 2019 May 24; 9(1), 7819.
2.Wenchu Ye, Ruohong Chen, Xiaoxuan Chen, Boyan Huang, Ruqin Lin, Xuan Xie, Jiongjie Chen, Jun Jiang, Yiqun Deng*, Jikai Wen*. AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1) by recruiting Sp1. FEBS J. 2019 Jun 14; 286 (21), 4215-4231.
3.Wenchu Ye, Ruqin Lin, Xiaoxuan Chen, Jiongjie Chen, Ruohong Chen, Xuan Xie, Yiqun Deng*, Jikai Wen*. T-2 toxin upregulates the expression of human cytochrome P450 1A1 (CYP1A1) by enhancing NRF1 and Sp1 interaction. Toxicol Lett.2019 Oct 15; 315, 77-86.
4.Shulin Tang, Shuang Chen, Boyan Huang, Jun Jiang, Jikai Wen*, and Yiqun Deng*. Deoxynivalenol induces inhibition of cell proliferation via the Wnt/beta-catenin signaling pathway. Biochemical Pharmacology. 2019 May 7; 166, 12-22. 
5.Xuan Xie^#, Jun Jiang, Wenchu Ye, Ruohong Chen, Yiqun Deng* and Jikai Wen*. Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter. Front. Pharmacol. 2018 Aug 17; 9:927.
6.Ruohong Chen, Jun Jiang, Zhangsheng Hu, Wenchu Ye, Qianqian Yuan, Mengyuan Li, Jikai Wen*, and Yiqun Deng*. Coordinated Transcriptional Regulation of Cytochrome P450 3As by Nuclear Transcription Factor Y and Specificity Protein 1. Mol Pharmacol 2019 May; 95:507–518.
7.Jikai Wen ^#, Peiqiang Mu ^#, and Yiqun Deng. Mycotoxins: cytotoxicity and biotransformation in animal cells, Toxicol Res. 2016 Jan 7; 5, 377-387.
8.Xin Liu^#, Jikai Wen^#, Ruohong Chen, Tingting Zhang, Jun Jiang, and Yiqun Deng*. T-2 toxin induces the expression of porcine CYP3A22 via the upregulation of the transcription factor, NF-Y. Biochimica et Biophysica Acta-General Subjects. 2016 Oct;1860(10): 2191-2201. 
9.Han Liu, Min Luo, and Jikai Wen*. mRNA stability in the nucleus. Journal of Zhejiang University-Science B. 2014 May;15, 444-454.
10.Khalid Al-Jubran ^#, Jikai Wen ^#, Akilu Abdullahi#, Subhendu Roy Chaudhury, Min Li, Preethi Ramanathan, Annunziata Matina, Sandip De, Kim Piechocki, Kushal Nivriti Rugjee, and Saverio Brogna. Visualization of the joining of ribosomal subunits reveals the presence of 80S ribosomes in the nucleus. RNA. 2013 Dec; 19, 1669-1683.
11.Jikai Wen, and Saverio Brogna. Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe. Embo Journal. 2010 May 5;29, 1537-1551.
12.Saverio Brogna, S., and Jikai Wen. Nonsense-mediated mRNA decay (NMD) mechanisms. Nature Structural & Molecular Biology. 2009 Feb; 16, 107-113.
13.Jikai Wen, and Saverio Brogna. Nonsense-mediated mRNA decay. Biochemical Society Transactions. 2008 Jun;36, 514-516.
14.Jikai Wen, Xian-en Zhang, Zhe Cheng, Hong Liu, Yafeng Zhou, Zhiping Zhang, Jihong Yang, and Jiaoyu Deng. A visual DNA chip for simultaneous detection of hepatitis B virus, hepatitis C virus and human immunodeficiency virus type-1. Biosens Bioelectron 2004 Feb 15;19, 685-92.

一種基因芯片上的酶標(biāo)信號(hào)檢測(cè)方法，專利號(hào)：ZL 02 1 15833.9，發(fā)明人：張先恩，鄧教宇，黃旭，張治平，邵文海，文繼開，陸紅兵，劉強(qiáng)。

一株高效降解嘔吐毒素的伊格爾茲氏菌Eggerthella sp. DII-9，專利號(hào)：ZL 2016 1 0785205.4，發(fā)明人：鄧詣群，高小娟，母培強(qiáng)，陳慶梅，文繼開。    

伊格爾茲氏菌Eggerthella sp. DII -9在降解嘔吐毒素中的應(yīng)用，專利號(hào)：ZL 2016 1 0785036.4，發(fā)明人：鄧詣群、母培強(qiáng)、高小娟、陳慶梅、文繼開。