張玲華

個人簡介

      華南農(nóng)業(yè)大學(xué)教授，博士生導(dǎo)師，廣東省千百十培養(yǎng)對象。2006年至今已在Vaccine、 Molecular Immunology、Developmental and Comparative Immunology等國際知名期刊發(fā)表30余篇論文，累積影響因子150.014，11項發(fā)明專利授權(quán)。作為學(xué)科帶頭人，積極推動學(xué)院“211”學(xué)科建設(shè)，協(xié)助組織并順利通過了生化與分子生物學(xué)廣東省重點學(xué)科中期評估。此外還兼任廣東省科技咨詢專家、教育部“博士后基金”評審專家等。

研究方向

微生物及免疫學(xué)

代表性成果(近五年的論文、專利等，2007年起)

(1) Shen H.K., Zhao Z.T., Zhao Z.J., Chen Y.Y., Zhang, L.H.* (張玲華) (2022). Native and Engineered Probiotics: Promising Agents against Related Systemic and Intestinal Diseases. International Journal of Molecular Sciences. 23;594 DOI: https://doi.org/10.3390/ijms23020594(*通訊作者，2021 SCI Impact factor, 6.258，中科院SCI期刊分區(qū)：2區(qū)，JCR分區(qū)：Q1）

(2) Weixiong Pan , Zengjue Zhao , Jiahui Wu , Qin Fan , Haobin Huang , Rongxiao He , Haokun Shen , Zitong Zhao , Saixiang Feng , Guanhua Gan , Zhiyang Chen , Miaopeng Ma , Chongjun Sun , Linghua Zhang*（張玲華）(2022) LACpG10-HL Functions Effectively in Antibiotic-Free and Healthy Husbandry by Improving the Innate Immunity, International Journal of Molecular Sciences(*通訊作者，2021 SCI Impact factor, 6.258，中科院SCI期刊分區(qū)：2區(qū)，JCR分區(qū)：Q1） 

(3) 賈軍皓，曹丁，陳勉華，趙培靜，明飛平，梁倩怡，李嘉怡，樊欽，鄧錦波，張淑霞，馬苗鵬，張玲華*，（2022）菌絲霉素在酪丁酸梭菌中的表達(dá)研究, 食品工業(yè)科技(*通訊作者，2022復(fù)合影響因子2.561，北大核心），

(4) 潘偉雄,陳鈺怡,趙锃玨,馮賽祥,仇微紅,葉賀佳,張玲華*，（2022）高效赤紅球菌協(xié)同CpGODN增強雞禽流感疫苗的免疫效力，畜牧獸醫(yī)學(xué)報(*通訊作者，2022復(fù)合影響因子 1.46，北大核心）

(5) Zhao. Z.J., He. R.X., Chu P.P., Cai H.M., Shen H.K., Zhao Z.T., Feng S.X., Cao D., Liao M., Gan G.H., Ye H.J., Chen Z.Y., Qiu W.H., Deng J.B., Ming F.P., Ma M.P., Jia J.H., Wu J.H., Huang H.B., Sun C.J., Li J.Y., Zhang, L.H.*(張玲華) (2021). YBX has functional roles in CpG-ODN against cold stress and bacterial infection of Misgurnus anguillicaudatus. Fish & Shellfish Immunology. 118: 72–84  DOI: https://doi.org/10.1016/j.fsi.2021.08.018(*通訊作者，2021SCI Impact factor, 4.581，中科院SCI期刊分區(qū)：1區(qū)，JCR分區(qū)：Q1）

(6) Ma M.P., Zhao Z.T., Liang Q.Y., Shen H.K., Zhao Z.J., Chen Z.Y., He R.X., Feng S.X., Cao D., Gan G.H., Ye H.J., Qiu W.H., Deng J.B., Ming F.P., Jia J.H., Sun C.H., Li J.Y., Zhang L.H.*(張玲華). (2021) Overexpression of pEGF improved the gut protective function of Clostridium butyricum partly through STAT3 signal pathway. Appl Microbiol Biotechnol. 105: 5973–5991 DOI: 10.1007/s00253-021-11472-y. (*通訊作者，2021SCI Impact factor, 4.810，中科院SCI期刊分區(qū)：2區(qū)，JCR分區(qū)：Q2）

(7) Sun C.J., Shen H.K., Cai H.M., Zhao Z.J., Gan G.H., Feng S.X., Chu P.P., Zeng M., Deng J.B., Ming F.P. Ma M.P., Jia J.H., He R.X., Cao D., Chen Z.Y., Li J.Y., Zhang L.H.*（張玲華）.(2021) Intestinal guard: Human CXCL17 modulates protective response against mycotoxins and CXCL17-mimetic peptides development. Biochemical Pharmacology. 188: 114586 DOI: 10.1016/j.bcp.2021.114586 (*通訊作者，2021SCI Impact factor, 5.860，中科院SCI期刊分區(qū)：2區(qū)，JCR分區(qū)：Q1）

(8) 李美娣，趙锃玨，劉漢清, 傅嘉莉，張玲華*，武力，（2021）腸道免疫相關(guān)的豬富含半胱氨酸腸蛋白2三維建模、分子特征及mRNA表達(dá)的組織分布，畜牧獸醫(yī)學(xué)報 (*通訊作者，2022復(fù)合影響因子 1.46，北大核心）

(9) Liang Q.Y., Liu J., Wei J.T., Jia J.H., Shen H.K., Chen W.L., Liang W.J., Gao B., Xu Z. H.*, Zhang L.H.* (張玲華）.（2020）The effect of Clostridium tyrobutyricum Spo0A overexpression in the intestine of mice. Beneficial Microbes. 2020; 11(6): 573-589 (*通訊作者，2021 SCI Impact factor, 4.205，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q3)

(10) Li J.Y., Shen H.K., Zhao Z.J., Cao D., Zeng M., Cai H.M., Wei J.T., Fan Q., Deng J.B., Ming F.P., Ma M.P., Liang Q.Y., Jia J.H., Zhang S.X., Zhang L.H.*（張玲華）.（2020）Protective effects of Clostridium butyricum against oxidative stress induced by food processing and lipid-derived aldehydes in Caco-2 cells. Applied Microbiology and Biotechnology. 104:9343-9361 (*通訊作者，2021SCI Impact factor, 4.810，中科院SCI期刊分區(qū)：2區(qū)，JCR分區(qū)：Q2)

(11) Li, J.Q., Fan, Q., Cai, H.M., Deng, J.B., Ming, F.P., Li, J.Y., Zeng, M., Ma, M.P., Zhao, P.J., Liang, Q.Y., Jia, J.H., Zhang, S.X., Zhang L.H.*（張玲華). (2020). Identification of RBP4 from bighead carp (Hypophthalmichthys nobilis) / silver carp (Hypophthalmichthys molitrix) and effects of CpG ODN on RBP4 expression under A. hydrophila challenge. Fish & Shellfish Immunology https://doi.org/10.1016/j.fsi.2020.03.036. (*通訊作者，2021SCI Impact factor, 4.581，中科院SCI期刊分區(qū)：1區(qū)，JCR分區(qū)：Q1)

(12) Cai, H.M., Wei, J.T., Shen, H.K., Li, J.Y., Fan, Q., Zhao, Z.Z., Deng, J.B., Ming, F.P., Zeng, M., Ma, M.P., Zhao, P.J., Liang, Q.Y., Jia, J.H., Zhang, S.X., Zhang L.H.*（張玲華). (2020). Molecular cloning, characterization and expression profiles of Annexin family (ANXA1~A6) in yellow catfish (Pelteobagrus fulvidraco) and ANX regulation by CpG ODN responding to bacterial infection. Fish & Shellfish Immunology 99, 609-630.( *通訊作者，2021SCI Impact factor, 4.581，中科院SCI期刊分區(qū)：1區(qū)，JCR分區(qū)：Q1)

(13) Deng J.B., Li J.Q., Ma M.P., Zhao P.J., Ming F.P., Lu Z.P., Shi J.Q., Fan Q, Liang Q.Y., Jia J.H., Li J.Y., Zhang S.X., Zhang L.H.*（張玲華）.（2020）Co-expressing GroEL-GroES, Ssa1-Sis1 and Bip-PDI chaperones for enhanced intracellular production and partial-wall breaking improved stability of porcine growth hormone. Microb Cell Fact. 19,35.( *通訊作者，2021 SCI Impact factor, 5.328，中科院SCI期刊分區(qū)：2區(qū)，JCR分區(qū)：Q2)

(14) Zhang S.X., Wu L., Chen J.W., Wei J.T., Cai H.M., Ma M.P., Zhao P.J., Ming F.P., Jia J.H., Li J.Y., Fan Q., Liang Q.Y., Deng J.B., Zeng M., Zhang L.H.*(張玲華).(2019) E?ects of porcine IL-17B and IL-17E against intestinal pathogenic microorganism. Molecular Immunology.116:151-159( *通訊作者，2021 SCI Impact factor, 4.407，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(15) Zhang S.X, Cai H.M., Cao D, Deng J.B., Jia J.H., Li J.Q., Ming F.P., Zhao P.J., Ma M.P., Liang Q.L., Zeng M., Zhang L.H.（張玲華）*. (2019) Recombinant plasmids containing CpG with porcine host defense peptides (PR-39/pBD-1) modulates the innate and adaptive intestinal immune responses (including maternal-derived) in piglets. Int. Immunopharmacol. 70, 467-476 ( *通訊作者，2021 SCI Impact factor, 4.932，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(16) Cai H.M., Deng J.B., Li J.Q., Ma M.P., Huang C, Zhao P, Ming F.P., Liang Q.Y., Jia J.H., Zhang S.X., Zeng M., Zhang, L.H. (張玲華)* (2019) Modulating the 3’ end-DNA and the fermentation process for enhanced production and biological activity of porcine interferon-gamma. PLoS ONE 14(3), e0214319. ( *通訊作者，2021 SCI Impact factor, 3.240，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(17) Yang, J., Cai, H.M., Liu, J., Z, Zeng. M., Cheng, Q.M, Zhang, L.H. (張玲華)*. (2018) Controlling AOX1 promoter strength in Pichia pastoris by manipulating poly (dA:dT) tracts. Scientific Reports, 8:1401-1412. ( *通訊作者，2021 SCI Impact factor, 4.379，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q1)

(18) Cai, H.M., Chen, J.W., Liu, J., Ming, F.P., Lu, Z.P., Cheng, Q.M., Yang, J., Zhang, L.H. (張玲華)*. (2017) CRIP1, a novel immune-related protein, activated by Enterococcus faecalis in porcine gastrointestinal epithelial cells. Gene, 598, 84-96. ( *通訊作者，2021 SCI Impact factor, 3.680，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(19) Yang, J., Lu, Z.P., Chen, J.W., Chu, P.P., Cheng, Q.M., Liu, J., Ming, F.P., Huang, C.Y., Xiao, A.J., Cai, H.M., Zhang, L.H. (張玲華)*. (2016) Effect of cooperation of chaperones and gene dosage on the expression of porcine PGLYRP-1 in Pichia pastoris. Applied Microbiology and Biotechnology, 100:5453–5465. (*通訊作者，2021SCI Impact factor, 4.810，中科院SCI期刊分區(qū)：2區(qū)，JCR分區(qū)：Q2）

(20) Cai, H.M., Kuang Z.S., Huang K.Y., Shi, J.Q., Zhao X.J., Chu, P.P., Huang, C.Y., Ming, F.P., Xia, F.G., Yang, J., Zhang, L.H. (張玲華)*. (2014) CpG oligodeoxynucleotide protect neonatal piglets from challenge with the enterotoxigenic E. coli , Veterinary Immunology and Immunopathology, 161, 66–76  (*通訊作者，2021SCI Impact factor, 2.046，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q4）

(21) Ming, F.P., Yang, J., Chu, P.P., Ma, M.P., Shi, J.Q., Cai, H.M., 參與人, Li, H.Z., Jiang, Z.G., Wang, W.F., Zhang, S.Q., Zhang L.H.(張玲華)*. (2013) Immunization of Aged Pigs with Attenuated Pseudorabies Virus Vaccine Combined with CpG Oligodeoxynucleotide Restores Defective Th1 Immune Responses, PLOS ONE,  8(6), 65536-65536 ( *通訊作者，2021 SCI Impact factor, 3.240，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(22) Ma, M.P., Wang, L.L., Yang, J., Cai, H.M., Shi, J.Q., Huang, Z.F., Zhang, S.Q., Zhang L.H.(張玲華)*. (2012) Age-related impaired Th1 responses to PRV vaccine in vivo in aged pigs, Molecular Immunology, 52, 217-222 ( *通訊作者，2021 SCI Impact factor, 4.407，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(23) Yang, J., Mao, M.P., Huang Z.F., Zhang, S.Q., Chen, S.F., Li, H.Z., Jiang, Z.G., Cao, G.J., Cao, D., Wang, X.F., Zhang L.H.(張玲華)*. (2012)  Innate defence regulator peptide synergizes with CpG ODN for enhanced innate instestinal immune responses in neonate piglets. Int. Immunopharmacol. 12(2), 415–424 ( *通訊作者，2021 SCI Impact factor, 4.932，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(24) Cao, D., Li, H.Z., Jiang, Z.G, Cheng, Q., Yang, Z.H., Xu, C.C., Cao, G.J., Zhang L.H.(張玲華)*. (2011) CpG oligodeoxynucleotide synergizes innate defense regulator peptide for enhancing the systemic and mucosal immune responses to pseudorabies attenuated virus vaccine in piglets in vivo.  Int. Immunopharmacol. 11, 748–754 ( *通訊作者，2021 SCI Impact factor, 4.932，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(25) Cao, D., Li, H.Z., Jiang, Z.G, Xu, C.C., Cheng, Q., Yang, Z.H., Cao, G.J., Zhang L.H.(張玲華)*. (2010) Synthetic innate defence regulator peptide enhances in vivo immunostimulatory effects of CpG-ODN in newborn piglets. Vaccine. 28, 6006–6013. ( *通訊作者，2021 SCI Impact factor, 3.641，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(26) Cheng, Q., Xu, C.C., Zhang L.H.(張玲華)*, Li, J.Q., Cao, T., Zhang, M.R. (2010) Administered CpG Oligodeoxynucleotide Induces mRNA expression of CXC and CC Chemokines at the Intestinal Mucosa and PBMCs in Piglets. Int. Immunopharmacol. 10, 611-618  ( *通訊作者，2021 SCI Impact factor, 4.932，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(27) Cheng, Q., Jiang, Z.G.,  Xu, C.C., Li, H.Z., Cao, D., Yang, Z.H., Cao, G.J., Zhang L.H.(張玲華)* (2010)  CpG oligodeoxynucleotide promotes protective immunity in the enteric mucosa and suppresses enterotoxigenic E. coli in the weaning piglets. Int. Immunopharmacol.  10, 1249–1260 ( *通訊作者，2021 SCI Impact factor, 4.932，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(28) Zhang L.H.(張玲華)*, Tian, X.S., Zhou, F.Z. (2008a) In vivo oral administration effects of variousoligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to pseudorabies attenuated virus vaccine in newborn piglets. Vaccine. 26, 224-233. ( *通訊作者，2021 SCI Impact factor, 3.641，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(29) Zhang L.H.(張玲華)*, Zhang, M.R., Li, J.Q., Cao, T., Tian, X.S., Zhou, F.Z. (2008b) Enhancement of mucosal immune responses by intranasal co-delivery of Newcastle disease vaccine plus CpG oligonucleotide in SPF chickens in vivo.  Research in Veterinary Science. 85,  495–502. ( *通訊作者，2021 SCI Impact factor, 2.534，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q1)

(30) Zhang L.H.(張玲華)*, Tian, X.S., Zhou, F.Z. (2007a)  In vivo immunostimulatory effects of CpG ODN in newborn piglets. Molecular Immunology. 44, 1238–1244. ( *通訊作者，2021 SCI Impact factor, 4.407，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(31) Zhang L.H.(張玲華)*, Tian, X.S., Zhou, F.Z. (2007b) In vivo effects of oligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to swine streptococcic septicemia vaccine in weaned piglets. Molecular Immunology. 44, 1141–1149. ( *通訊作者，2021 SCI Impact factor, 4.407，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(32) Zhang L.H.(張玲華)*, Tian, X.S., Zhou, F.Z. (2007c) Vaccination with porcine reproductive and respiratory syndrome killed virus vaccine and immunostimulatory oligodeoxynucleotides induces specific immunity in piglets. Vaccine. 25, 1735–1742. ( *通訊作者，2021 SCI Impact factor, 3.641，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(33) Zhang L.H.(張玲華)*, Tian, X.S., Zhou, F.Z. (2007d) Vaccination with Newcastle disease vaccine and CpG oligodeoxynucleotides induces specific immunity and protection against Newcastle disease virus in SPF chicken. Veterinary Immunology and Immunopathology. 115, 216–222. (*通訊作者，2021SCI Impact factor, 2.046，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q4）

(34) Zhang L.H.(張玲華)*, Tian, X.S., Zhou, F.Z. (2007e) Intranasal administration of CpG oligonucleotides induces mucosal and systemic Type 1 immune responses and adjuvant activity to porcine reproductive and respiratory syndrome killed virus vaccine in piglets in vivo. International Immunopharmacology. 7(13), 1732–1740. (*通訊作者，2021SCI Impact factor, 4.932，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2）

(35) Zhang L.H.(張玲華)*, Tian, X.S., Zhou, F.Z. (2007f) CpG oligodeoxynucleotides augment the immune responses of piglets to swine Pasteurella multocida living vaccine in vivo. Research in Veterinary Science. 83(2),171-181. ( *通訊作者，2021 SCI Impact factor, 2.534，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q1)

(36) Zhang L.H.(張玲華)*, Guo, Y., Tian, X.S., Zhou, F.Z. (2006a) Co-administration of porcine-specific CpG oligodeoxynucleotide enhances the immune responses to pseudorabies attenuated virus vaccine in newborn piglets in vivo. Developmental and Comparative Immunology. 30(6), 589-596. ( *通訊作者，2021 SCI Impact factor, 3.636，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q1)

(37) Zhang L.H.(張玲華)*, Tian, X.S., Guo, Y., Zhou, F.Z. (2006b) Effects of CpG ODN on CD4+ and CD8+ T subpopulations in the immune response to porcine reproductive and respiratory syndrome killed virus vaccine. Vaccine. 24(11), 1874-1879 . ( *通訊作者，2021 SCI Impact factor, 3.641，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2)

(38) Zhang L.H.(張玲華)*, Tian, X.S., Zhou, F.Z. (2006c) The efficacy of CpG oligodinucleotides, in combination with conventional adjuvants, as immunological adjuvants to swine streptococcic septicemia vaccine in piglets in vivo. International Immunopharmacology. 6(8), 1267-1276. (*通訊作者，2021SCI Impact factor, 4.932，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2）

(39) Zhang L.H.(張玲華)*, Tian, X.S., Zhou, F.Z. (2006d) In vivo effects of oligodeoxynucleotides containing synthetic immunostimulatory motifs in weaned piglets. International Immunopharmacology. 6(10),1623-1631. (*通訊作者，2021SCI Impact factor, 4.932，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2）

(40) Zhang L.H.(張玲華)*, Guo, Y., Tian, X.S., Zhou, F.Z. (2006e) CpG oligodinucleotides induce strong humoral and cellular responses to swine streptococcic septicemia vaccine in piglets in vivo. International Immunopharmacology. 6(3), 342-350. (*通訊作者，2021SCI Impact factor, 4.932，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q2）

(41) Zhang L.H.(張玲華)*, Tian, X.S., Guo, Y., Zhou, F.Z. (2006f) The effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of the newborn piglets inoculated with pseudorabies attenuated vaccine. Research in Veterinary Science. 80, 281-286. ( *通訊作者，2021 SCI Impact factor, 2.534，中科院SCI期刊分區(qū)：3區(qū)，JCR分區(qū)：Q1)

相關(guān)專利

(1) 張玲華，田興山，鄺哲師，陳薇，李健雄，有益微生物制劑穩(wěn)定化預(yù)處理工藝，2006.12，中國，ZL200310117512.8

(2) 鄺哲師，田興山，張玲華，陳薇，李健雄，“有益微生物制劑穩(wěn)定化后處理工藝”， 2006.8，中國， ZL200310117511.3

(3) 鄺哲師，張玲華，徐志宏，“一種微生物轉(zhuǎn)化菠蘿渣為生物飼料的制備方法”, 2008.1，中國， ZL200610033024.2

(4) 張玲華，李華周，姜增固。“一種高效CpG制劑及其制備方法和應(yīng)用”， 2014.6，中國，ZL201210090979.7

(5) 張玲華，鄺哲師，蔡海明，趙祥杰，楚品品，葉明強，“一種高效提高枯草芽孢桿菌出芽率的方法”，專利號：ZL201410162370.5

(6) 張玲華，蔡海明，馬苗鵬，周潔安，“一種高效抗炎性PB ODN序列及其應(yīng)用”，專利號：ZL 20151043403.5

(7) 張玲華，馬苗鵬，楊軍，“一種嗜酸乳酸桿菌與醋酸桿菌混合發(fā)酵的方法”，專利號：ZL201510335715.7

(8) 江學(xué)斌，張玲華，胡位榮，馬苗鵬，黃瀚威，“一種高效降低水體COD沼澤紅假單胞菌的培養(yǎng)基”專利號：ZL201610026084.5

(9) 張玲華，黃朝遠(yuǎn)，楊軍，蔡海明，馬苗鵬，“一種優(yōu)化的pIFN-γ肽鏈及在提高畢赤酵母分泌表達(dá)豬IFN-γ產(chǎn)量和活性中的應(yīng)用”，專利號：ZL 201611154681.2 

(10) 張玲華，賈軍皓，曹丁，馬苗鵬，明飛平，“一種優(yōu)化的pGH基因、蛋白及在提高畢赤酵母分泌表達(dá)pGH產(chǎn)量和活性中的應(yīng)用” ，2021.5專利號：ZL 201910205418.9

(11) 張玲華，賈軍皓，楚品品，曹丁，馬苗鵬，鄧錦波，明飛平，“一種促進枯草芽孢桿菌自然生長轉(zhuǎn)化的培養(yǎng)基組合及其轉(zhuǎn)化方法”，2021.6.15 專利申請?zhí)枺篫L201911243090.6

(12) 張玲華，賈軍皓，馬苗鵬，“一種對豬具有特異性免疫刺激作用的CpG-ODN及其應(yīng)用”，2023.1.17 專利號：ZL201910229571.5

承擔(dān)課題

(1) 2022.5-2025.10 主持橫向項目“高效腸道修復(fù)分泌EGF多能型AKKermansia muciniphila菌劑的研制及應(yīng)用示范”（200萬元，項目編號: h20220334，在研、主持。）

(2) 廣州市科技計劃項目民生科技攻關(guān)計劃(2020)，家禽多聯(lián)多價滅活疫苗新型專用Toll樣受體激動佐劑的研發(fā)及應(yīng)用，202002020056，2020/04-2023/03、100萬元、在研、主持。

(3) 橫向項目，新型裂裥菌素-Toll5激動劑納米生物材料研制及應(yīng)用示范、2019/10-2022/10、200萬元、在研、主持。

(4) 廣州市重點科技項目，新型Plectasin分泌型益生菌劑高效防治羅非魚鏈球菌病研發(fā)及應(yīng)用，2019/01-2022/12、45萬元、在研、主持。

(5) 廣東省自然科學(xué)基金自由申請項目，CRIP1通過調(diào)節(jié)Zn2+水平控制豬腸道沙門氏菌感染的機制研究、 2018/01-2021/12、10萬元、在研、主持。

(6) 廣州市重點科技項目，３-OH PAME淬滅酶分泌型高效青枯病復(fù)合生防菌劑研發(fā)及應(yīng)用， 2018/01-2021/12、45萬元、在研、主持。

(7) 廣東省自然科學(xué)基金自由申請項目，HPS感染細(xì)胞模型的建立及新型Sup ODN抗HPS感染機制研究、 2015/01-2017/12、10萬元、在研、主持。

(8) 廣州市產(chǎn)學(xué)研協(xié)同創(chuàng)新重大專項目，益生菌-荔枝多酚對仔豬腹瀉的防治研究，2016/01-2019/12、100萬元、在研、合作主持。

(9) 橫向項目，重組豬伽馬干擾素在畢赤酵母中的分泌表達(dá)及其活性分析，2017-2020、30萬元、主持。（已完成）

(10) 2012.1-2014.12　主持廣東省教育部產(chǎn)學(xué)研結(jié)合項目“分泌型畢赤酵母發(fā)酵制備飼用抗菌肽 PR39 的研究及應(yīng)用”（ 30萬元，NO：2011B090300020，已完成）

(11) 2011.1-2013.12　主持國家自然科學(xué)基金“CpG ODN 通過NF-κB 信號系統(tǒng)延緩T 細(xì)胞衰老的分子機制”（34萬元，NO：31072114，已完成）

(12) 2010.1-2012.12　主持廣州市重點科技項目“抗仔豬斷奶應(yīng)激腹瀉CpG制劑關(guān)鍵技術(shù)研究及示范”（15萬元，NO: 2010Z1-E311，已完成）

(13) 2009.9-2012.9  主持廣東省農(nóng)業(yè)攻關(guān)項目“幼豬高熱病疫苗免疫增效劑CpG的研究及應(yīng)用”（5萬元，NO:  2009B020307010 ，已完成）

(14) 2008.8-2010.12　主持美國Merial合作項目“CpG仔豬抗病免疫機理研究”（24萬元，已完成）

(15) 2008.1-2010.12　主持廣州市重點科技項目“高效功能型硝酸鹽降解菌群的構(gòu)建及其制劑的生產(chǎn)和應(yīng)用”，（12萬元，NO：2008-Z1－E081，已完成）

(16) 2007.10-2008.9　主持美國Merial合作項目“CpG誘導(dǎo)仔豬先天性免疫能力”（51.3萬元，已完成）

(17) 2006.9-2009.8　主持廣東省農(nóng)業(yè)攻關(guān)項目“高效硝酸鹽降解功能菌群的構(gòu)建及應(yīng)用”（62萬元，NO: 2006B20601011，已完成）

獲獎成果

（1）田興山，張玲華，石和榮，鄺哲師，李健雄，柯浩，潘木水，唐小俊，馬江耀，陳薇，黃曉光，謝海燕，周風(fēng)珍，李國立，孫曉剛. “有益微生物制劑促進動物生長的研究及應(yīng)用” ，2005獲廣東省科技進步二等獎。
（2）田興山, 石和榮，張玲華，張彪，鄺哲師，唐小俊，柯  浩，李健雄，馬江耀，周風(fēng)珍，陳薇. “對蝦生態(tài)養(yǎng)殖技術(shù)研究及應(yīng)用”, 2005年度獲得茂名市科技進步三等獎。