吳駿

2006/08-現(xiàn)在，華南農(nóng)業(yè)大學(xué)，生命科學(xué)學(xué)院生化與分子生物學(xué)系，副教授

研究聚焦霉菌毒素（黃曲霉毒素，嘔吐毒素，T-2毒素，玉米赤霉烯酮等）在動(dòng)物體內(nèi)的關(guān)鍵代謝酶及催化機(jī)制。主要利用分子生物學(xué)，生物化學(xué)，計(jì)算生物學(xué)，酶學(xué)等方法和技術(shù)系統(tǒng)解析參與霉菌毒素在動(dòng)物體內(nèi)代謝的關(guān)鍵酶及其代謝轉(zhuǎn)化的分子機(jī)理。

1. 廣州市科技計(jì)劃項(xiàng)目，201607010178，黃曲霉毒素B1在豬肝臟代謝關(guān)鍵酶的底物選擇和調(diào)控的分子機(jī)制，2016/04-2019/03，20萬(wàn)，已結(jié)題，主持
2. 國(guó)家自然科學(xué)基金青年基金，31101852，黃曲霉毒素在豬體內(nèi)代謝的關(guān)鍵細(xì)胞色素P450氧化酶的篩選、確定及催化機(jī)制研究，2012/01-2014/12，23萬(wàn)元，已結(jié)題，主持
3. 科技部“973”計(jì)劃課題，2009CB118802，受試化合物在畜禽代謝關(guān)鍵酶的功能及結(jié)構(gòu)研究， 2009/01-2013/12，412萬(wàn)元，已結(jié)題，參加

1. Wanying Wu, Tianqing Jiang, Haihui Lin, Chao Chen, Lingling Wang, Jikai Wen, Jun Wu*, Yiqun Deng*. The Specific Binding and Promotion Effect of Azoles on Human Aldo-Keto Reductase 7A2. Metabolites, 2023, 13(5):601.

2. Jun Wu^#, Sisi Zhu^#, Yunbo Wu, Tianqing Jiang, Lingling Wang, Jun Jiang, Jikai Wen, and Yiqun Deng. Multiple CH/π interactions maintain the binding of aflatoxin B1 in active cavity of human cytochrome P450 1A2. Toxins, 2019, 11(3): 158.

3. Sisi Zhu^#, Jun Wu^#, Silin Liu, Tianqing Jiang, Yiqun Deng*, Phe-125 and Phe-226 of pig cytochrome P450 1A2 stabilize the binding of aflatoxin B1 and 7-ethoxyresorufin through the key CH/π interactions. Biochemical Pharmacology, 2019, 166: 292-299.

4. Lingling Wang^#, Jun Wu^#, Zhiwen Liu, Yutao Shi, Jinqiu Liu, Xiaofan Xu, Shuxian Hao, Peiqiang Mu, Fengru Deng, and Yiqun Deng, Aflatoxin B1 Degradation and Detoxification by Escherichia coli CG1061 Isolated From Chicken Cecum. Frontiers in Pharmacology, 2019, 9:1548. doi: 10.3389/fphar.2018.01548

5. Haoran Jiang, Jun Wu, Feiyong Zhang, Jikai Wen, Jun Jiang, and Yiqun Deng, The critical role of porcine cytochrome P450 3A46 in the bioactivation of aflatoxin B1. Biochemical Pharmacology, 2018, 156:177-185.

6. Jun Wu^#, Ruohong Chen^#, Caihui Zhang, Kangbai Li, Weiying Xu, Lijuan Wang, Qingmei Chen, Peiqiang Mu, Jun Jiang, JikaiWen and Yiqun Deng*. Bioactivation and regioselectivity of pig cytochrome P450 3A29 towards aflatoxin B1. Toxins, 2016, 8(9): 267-283.

7. Jun Wu^#, Weiying Xu^#, Caihui Zhang, Qing Chang, Xianqing Tang, Kangbai Li, Yiqun Deng*. Trp266 determines the binding specificity of a porcine aflatoxin B1 aldehyde reductase for aflatoxin B1-dialdehyde. Biochemical Pharmacology, 2013, 86(9):1357-1365.

8. Xianqing Tang, Peiqiang Mu, Jun Wu, Jun Jiang, Caihui Zhang, Ming Zheng, Yiqun Deng*. Carbonyl Reduction of Mequindox by Chicken and Porcine Cytosol and Cloned CBR1. Drug Metabolism and Disposition, 2012, 40(4): 788-795.

9. Peiqiang Mu, Ming Xu, Lei Zhang, Kaixin Wu, Jun Wu, Jun Jiang, Qingmei Chen, Lijuan Wang, Xianqing Tang, Yiqun Deng*. Proteomic changes in chicken primary hepatocytes exposed to T-2 toxin are associated with oxidative stress and mitochondrial enhancement. Proteomics, 2013, 13(21):3175-3188.

10. Jing Liu^#, Man Ouyang^#, Jun Jiang, Peiqiang Mu, Jun Wu, Qi Yang, Caihui Zhang, Weiying Xu, Lijuan Wang, Michael S.Y. Huen*, Yiqun Deng*. Mequindox induced cellular DNA damage via generation of reactive oxygen species. Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 2012, 741(1-2): 70-75.

11. Shirley M.H. Sy^#, Jun Jiang^#, Sui-sui Dong, Gabriel Tsz-Mei Lok, Jun Wu, Hua Cai, Enoch S.L. Yeung, Jun Huang, Junjie Chen, Yiqun Deng*, Michael S.Y. Huen*. Critical roles of ring finger protein RNF8 in replication stress responses. Journal of Biological Chemistry, 2011, 286(25): 22355-22361.

12. Jing Liu, Xiaohu Ge, Man Ouyang, Xianqing Tang, Jun Wu, Junping Wang, Jun Jiang, Michael S.Y. Huen*, Yiqun Deng*. Catalytic characteristics of CYP3A22-dependent mequindox detoxification. Catalysis Communications, 2011, 12(7): 637-643.

13. Xiaohu Ge^#, Junping Wang^#, Jing Liu, Jun Jiang, Huina Lin, Jun Wu, Man Ouyang, Xianqing Tang, Ming Zheng, Ming Liao, Yiqun Deng*. The catalytic activity of cytochrome P450 3A22 is critical for the metabolism of T-2 toxin in porcine reservoirs. Catalysis Communications, 2010, 12(2): 71-75.

14. Jun Wu, Fen Du, Peng Zhang, Izhar Ahmed Khan, Jie Chen, Yi Liang*. Thermodynamics of the interaction of aluminum ions with DNA: Implications for the biological function of aluminum. Journal of Inorganic Biochemistry, 2005, 99: 1145-1154.

15. Hong Xu, Yi Liang*, Peng Zhang, Fen Du, Bing-Rui Zhou, Jun Wu, Jian-Hong Liu, Zhi-Gang Liu, Liang-Nian Ji Biophysical studies of a ruthenium(II) polypyridyl complex binding to DNA and RNA prove that nucleic acid structure has significant effects on binding behaviors. Journal of Biological Inorganic Chemistry, 2005, 10(5): 529-538.