| 教授 生物化學(xué)系 碩士生導(dǎo)師 Email：jiangjun@scau.edu.cn |
個(gè)人簡(jiǎn)介
蔣珺，已發(fā)表SCI論文57篇，其中以第一作者或通訊作者（含同等貢獻(xiàn)）在Nucleic Acids Research，Oncogene，Molecular & Cellular Proteomics，Archives of Toxicology，Journal of Agricultural and Food Chemistry等國(guó)際知名期刊發(fā)表SCI論文19篇；主持國(guó)家重點(diǎn)研發(fā)項(xiàng)目子課題、國(guó)家自然科學(xué)基金青年項(xiàng)目、廣東省自然科學(xué)基金面上項(xiàng)目等課題10余項(xiàng)；以學(xué)術(shù)骨干/核心成員參與973計(jì)劃子課題、NSFC-廣東省聯(lián)合基金重點(diǎn)項(xiàng)目、廣東省自然科學(xué)基金研究團(tuán)隊(duì)、粵港真菌毒素生物防控團(tuán)隊(duì)等多項(xiàng)重點(diǎn)項(xiàng)目；入選廣東省高等學(xué)校優(yōu)秀青年教師培養(yǎng)計(jì)劃、廣州市珠江科技新星等人才項(xiàng)目；作為第二完成人獲得2021年度第十二屆大北農(nóng)科技獎(jiǎng)創(chuàng)新獎(jiǎng)；擔(dān)任中國(guó)生物化學(xué)與分子生物學(xué)會(huì)農(nóng)業(yè)分會(huì)青年委員會(huì)副主任，廣東省生物化學(xué)與分子生物學(xué)學(xué)會(huì)理事以及Journal of Agricultural and Food Chemistry, Chemical Research in Toxicology, Environmental Pollution,Chemosphere, Toxicology等知名期刊審稿人。
學(xué)習(xí)經(jīng)歷
1.2004/09-2009/07，中國(guó)科學(xué)院水生生物研究所，博士，導(dǎo)師：桂建芳院士
2.2000/09-2004/07，華中師范大學(xué)，生命科學(xué)學(xué)院，學(xué)士
工作經(jīng)歷
1.2022/12至今，華南農(nóng)業(yè)大學(xué)，生命科學(xué)學(xué)院，教授
2.2019/09-2020/06，美國(guó)加州大學(xué)歐文分校，訪問(wèn)學(xué)者
3.2011/07-2022/11，華南農(nóng)業(yè)大學(xué)，生命科學(xué)學(xué)院，副研究員
4.2011/04-2011/10，香港大學(xué)，李嘉誠(chéng)醫(yī)學(xué)院，高級(jí)研究助理
5.2009/07-2011/07，華南農(nóng)業(yè)大學(xué)，生命科學(xué)學(xué)院，博士后，合作導(dǎo)師：鄧詣群教授
研究方向
1. 畜禽霉菌毒素中毒病的發(fā)生發(fā)展機(jī)制與防控
2. 參與霉菌毒素代謝關(guān)鍵酶的功能、結(jié)構(gòu)與調(diào)控
3. 細(xì)胞周期調(diào)控與腫瘤發(fā)生
發(fā)表論文（*通訊作者，#第一作者）
2025年
1. Wandi Bu#, Xinyao Wu#, Zhihang Zhong, Yaping Fang, Shuang Chen, Jun Jiang*, Yiqun Deng*. Immunotoxicity and effects of gut microbiota in chicks exposed to low doses of deoxynivalenol and 15-acetyl-deoxynivalenol. Toxicology and Applied Pharmacology. 2025 Sep 15:505:117568.
2. Wandi Bu#, Xinyao Wu#, Zhihang Zhong, Yuekai Li, Yaping Fang, Shuang Chen, Zige Wang,Ying Hong, Feiyang Dai, Yan Wang, Jun Jiang*, Yiqun Deng*. Epmedin C Alleviates Deoxynivalenol-Induced Immunotoxicity by Inhibiting Caspase?1 Activation in Chicken Macrophages. Journal of Agricultural and Food Chemistry. 2025 Sep 17;73(37):23617-23632.
3. Tianqing Jiang, Luyu Deng, Ruqin Lin, Jun Jiang, Jian Zeng, Jikai Wen, Yiqun Deng. New insights into the mechanism of T-2 toxin cytotoxicity: stress granules inhibit the mTORC2/AKT signaling pathway, FOOD BIOSCIENCE, 2025, 68: 106806.
4. Yuting Wu, Ruqin Lin, Qianqian Yuan, Yu Sun, Yiwen Yuan, Tianqing Jiang, Jun Jiang, Peiqiang Mu, Jikai Wen, Yiqun Deng. Mechanistic insights into deoxynivalenol-Induced hepatic cholestasis via IRE1α/HNF1α/FXR signaling dysregulation in mice. Ecotoxicology and Environmental Safety. 2025 Aug:301:118489.
5. Ziming Huang, Miao Li, Zhiqin He, Xiliang Yan, Yinbao Wu, Peiqiang Mu, Jun Jiang, Xu Wang, Yan Wang. Rosemary Extract Reduces Odor in Cats Through Nitrogen and Sulfur Metabolism by Gut Microbiota-Host Co-Modulation. Animals (Basel). 2025 Jul 16;15(14):2101.
6. Xiaoying Jian, Duo Zheng, Shengping Pang, Peiqiang Mu, Jun Jiang, Xu Wang, Xiliang Yan, Yinbao Wu, Yan Wang. Gut Microbiota-A Powerful Tool for Improving Pig Welfare by Influencing Behavior Through the Gut-Brain Axis. Animals (Basel). 2025 Jun 26;15(13):1886.
7. Qiang Xu, Ruqin Lin, Tianqing Jiang, Luyu Deng, Yuting Wu, Yuan, Qianqian Yuan, Xueying Qi, Peiqiang Mu, Jun Jiang, Yiqun Deng, Jikai Wen. Enhanced SIRT1-TFEB Interaction Promotes Lysosome Biogenesis and Autophagy by Reducing TFEB Acetylation: Revealing the Enterotoxicity Disparity of Deoxynivalenol and T-2 Toxin. Journal of Agricultural and Food Chemistry. 2025 May 28;73(21):12993-13005.
8. Fengru Deng#, Chuying Yao#, Linyu Ke, Meichan Chen, Mi Huang, Jikai Wen, Qingmei Chen, Jun Jiang, Yiqun Deng*. Emerging threat to antibiotic resistance: Impact of mycotoxin deoxynivalenol on gut microbiota and clonal expansion of extensively drug-resistant enterococci. Environment International, 2025,197:109353.
2024年
1. Zige Wang, Qiang Huang, Feiyong Zhang, Jiajun Wu, Lingling Wang, Yu Sun, Yiqun Deng*, Jun Jiang*, The key role of porcine cytochrome P450 2A19 in the bioactivation of aflatoxin B1 in the liver. Journal of Agricultural and Food Chemistry. 2024 Jan 31;72(4):2334-2346.
2. Jianhong Xia#, Haiyun Wang#, Zhihang Zhong, Jun Jiang*, Inhibition of PIKfyve Leads to Lysosomal Disorders via Dysregulation of mTOR Signaling. Cells. 2024, 13, 953.
3. Lingling Wang, Zifeng Deng, Jieying Huang, Tingyuan Li, Jun Jiang, Wence Wang, Yu Sun, Yiqun Deng*. Zearalenone-induced hepatointestinal toxicity in laying hens: unveiling the role of gut microbiota and fecal metabolites. Poultry Science, 2024 November;103(11):1-14.
4. XingSheng Sun, Lin Ruqin, Xinxia Lu, Zhikai Wu, Xueying Qi, Tianqing Jiang, Jun Jiang, Peiqiang Mu, Qingmei Chen, Jikai Wen* & Yiqun Deng*. UPF3B modulates endoplasmic reticulum stress through interaction with inositol-requiring enzyme-1α. Cell Death & Disease, 2024 August 13;15:587.
2023年
1. Jiahui Zhu, Guihong Li, Qiang Huang, Jikai Wen, Yiqun Deng*, Jun Jiang*. TET3-mediated DNA demethylation and chromatin remodeling regulate T-2 toxin-induced human CYP1A1 expression and cytotoxicity in HepG2 cells. Biochemical Pharmacology. 2023 May; 211:115506.
2. Caizhu Wang#, Ruqin Lin#, Xueying Qi, Qiang Xu, Xingsheng Sun, Yurong Zhao, Tianqing Jiang, Jun Jiang, Yu Sun, Yiqun Deng*, Jikai Wen*. Alternative glucose uptake mediated by β-catenin/RSK1 axis under stress stimuli in mammalian cells. Biochemical pharmacology. 2023, Aug; 214, 115645.
3. Tianqing Jiang, Xueying Qi, Ruqin Lin, Jun Jiang, Jikai Wen*, Yiqun Deng*. T-2 toxin and deoxynivalenol (DON) exert distinct effects on stress granule formation depending on altered activity of SIRT1. Ecotoxicology and Environmental Safety. 2023 Jul 1; 259:115028.
4. Danyang Li, Guoqiang Liang, Peiqiang Mu, Jinquan Lin, Jiarun Huang, Chongwen Guo, Yang Li, Ruqin Lin, Jun Jiang, Jun Wu, Yiqun Deng*, Jikai Wen*. Improvement of catalytic activity of sorbose dehydrogenase for deoxynivalenol degradation by rational design. Food Chemistry. 2023 Oct 15; 423:136274.
其他代表性論文
1. Shirley M.H. Sy#, Jun Jiang#, Wai Sum O, Yiqun Deng*, Michael S.Y. Huen*. The Ubiquitin Specific Protease USP34 Promotes Ubiquitin Signaling at DNA Double-Strand Breaks. Nucleic Acids Research. 2013 Oct; 41(18): 8572-8580.
2. Jun Jiang#, Shulin Tang#, Jianhong Xia, Jikai Wen, Shuang Chen, Xiaodong Shu, Michael S. Y. Huen, Yiqun Deng*. C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling. Oncogene. 2018 May; 37: 2992-3005.
3. Jianshe Wang#, Jun Jiang#, Hongxia Zhang, Junping Wang, Hua Cai, Cheng Li, Kangbai Li, Jing Liu, Xuejiang Guo, Guangxun Zou, Dazhi Wang, Yiqun Deng*, Jiayin Dai*.Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes. Molecular & Cellular Proteomics.2011 Sep; 10(9): M111.008748, 1-18.
4. Shirley M.-H. Sy#, Jun Jiang#, Sui-sui Dong, Gabriel Tsz-Mei Lok, Jun Wu, Hua Cai, Enoch S.L. Yeung, Jun Huang, Junjie Chen, Yiqun Deng*, Michael S.Y. Huen*. Critical roles of ring finger protein RNF8 in replication stress responses. Journal of Biological Chemistry. 2011 Jun 24; 286(25): 22355-22361.
主持與參加的科研項(xiàng)目
1. 國(guó)家重點(diǎn)研發(fā)子課題，2023，主持
2. 廣東省自然科學(xué)基金面上項(xiàng)目，2023，主持
3. 國(guó)家自然科學(xué)基金聯(lián)合基金，2024，參與
4. 區(qū)域聯(lián)合基金-粵港澳研究團(tuán)隊(duì)項(xiàng)目，2022，參與
入選的人才基金項(xiàng)目
1.廣州市科技計(jì)劃項(xiàng)目珠江科技新星專項(xiàng)，2016
2.廣東省高等學(xué)校優(yōu)秀青年教師培養(yǎng)計(jì)劃，2015
3.廣東省高等學(xué)校“千百十人才培養(yǎng)工程”第八批校級(jí)培養(yǎng)對(duì)象，2014
授權(quán)發(fā)明專利
1.文繼開(kāi)；陳慶梅；張艷；鄧詣群；吳駿；蔣珺；胡泰斗；胡章盛；一種基于人鐵蛋白的納米酶及其制備方法，2022.04.08，中國(guó)，ZL201810470199.2.
2.鄧詣群；汪玲玲；蔣珺；吳駿；母培強(qiáng)；鄧?guó)P如；大腸桿菌在降解代謝黃曲霉毒素B1方面的應(yīng)用，2020-08-07，中國(guó)，ZL201810316911.3.
3.鄧詣群；汪玲玲；蔣珺；吳駿；母培強(qiáng)；鄧?guó)P如；一株高效降解黃曲霉毒素B1的大腸桿菌CG1061，2020-08-07，中國(guó)，ZL201810317744.4.
學(xué)術(shù)兼職
(1) 中國(guó)生物化學(xué)與分子生物學(xué)會(huì)農(nóng)業(yè)分會(huì)青年委員會(huì)副主任
(2) 廣東省生物化學(xué)與分子生物學(xué)學(xué)會(huì)青年委員會(huì)常務(wù)委員
(3) 廣東省生物化學(xué)與分子生物學(xué)學(xué)會(huì) 理事
(4) 廣東省生物物理學(xué)會(huì)常務(wù)理事
學(xué)術(shù)獎(jiǎng)勵(lì)
1.蔣珺(2/10); 飼料中常見(jiàn)霉菌毒素的分子毒理與生物防控, 大北農(nóng)科技獎(jiǎng)獎(jiǎng)勵(lì)委員會(huì), 其他, 其他, 2021(鄧詣群; 蔣珺; 文繼開(kāi); 母培強(qiáng); 汪玲玲; 吳駿; 林如琴; 陳慶梅; 鄧?guó)P如; 孫峪) (科研獎(jiǎng)勵(lì))
