 | 教授 博士生導(dǎo)師 性別: 男
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個(gè)人簡(jiǎn)介
鄧詣群，1975年出生，博士。致力于動(dòng)物蛋白質(zhì)（酶）的功能、結(jié)構(gòu)及調(diào)控機(jī)理研究，重點(diǎn)關(guān)注真菌毒素等外源化合物在動(dòng)物體內(nèi)的分子毒理和代謝轉(zhuǎn)化機(jī)制。入選國(guó)家“萬(wàn)人計(jì)劃”科技創(chuàng)新領(lǐng)軍人才（2016年）、廣東省“珠江學(xué)者”特聘教授（2009年）、教育部“新世紀(jì)優(yōu)秀人才支持計(jì)劃”（2008年）；兼任中國(guó)生物化學(xué)與分子生物學(xué)會(huì)理事、廣東省農(nóng)業(yè)生物蛋白質(zhì)功能與調(diào)控重點(diǎn)實(shí)驗(yàn)室主任。
主持國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973）課題、NSFC-廣東聯(lián)合基金重點(diǎn)項(xiàng)目、廣東省自然科學(xué)基金研究團(tuán)隊(duì)項(xiàng)目等；以通訊/共同通訊作者身份在 Cell Death and Differentiation, Nucleic Acids Research和Oncogene 等期刊發(fā)表47篇論文（1篇獲F1000推薦）；授權(quán)5項(xiàng)國(guó)家發(fā)明專利；榮獲全國(guó)師德標(biāo)兵、教育部霍英東青年教師獎(jiǎng)（二等獎(jiǎng)）、廣東省丁穎科技獎(jiǎng)等。
工作經(jīng)歷
2007.12 ~ 至今 華南農(nóng)業(yè)大學(xué)生命科學(xué)學(xué)院 教授
2007.07 ~ 2007.12 美國(guó)康奈爾大學(xué)醫(yī)學(xué)院生化系 Instructor
2002.09 ~ 2007.06 美國(guó)康奈爾大學(xué)醫(yī)學(xué)院生化系 Postdoctoral Fellow
2000.08 ~ 2002.02 香港科技大學(xué)生化系 Visiting Scholar
學(xué)習(xí)經(jīng)歷
| 學(xué)位 | 學(xué)歷 | 學(xué)科門(mén)類 | 專業(yè) | 畢業(yè)學(xué)校 | 類型 | 入學(xué)時(shí)間 | 畢業(yè)時(shí)間 |
|---|---|---|---|---|---|---|---|
博士 | 博士 研究生 | 醫(yī)學(xué) | 生化與分子 生物學(xué) | 中山大學(xué)中山 醫(yī)學(xué)院 | 全日制 | 1999-09 | 2002-06 |
碩士 | 碩士 研究生 | 醫(yī)學(xué) | 生化與分子 生物學(xué) | 中山醫(yī)科大學(xué) | 全日制 | 1996-09 | 1999-06 |
學(xué)士 | 大學(xué)本科 | 醫(yī)學(xué) | 臨床醫(yī)學(xué) | 皖南醫(yī)學(xué)院 | 全日制 | 1991-09 | 1996-06 |
研究方向
1. 真菌毒素的分子毒理和代謝轉(zhuǎn)化
2. 動(dòng)物蛋白質(zhì)（酶）功能、結(jié)構(gòu)與調(diào)控
代表性論文
Selected publications related to current work (*corresponding author ):
Research articles:
Han Qiao, Tianqing Jiang, Peiqiang Mu, Xiaoxuan Chen, Xianhui Wen, Zhangsheng Hu, Shulin Tang, Jikai Wen*, Yiqun Deng*. Cell fate determined by the activation balance between PKR and SPHK1. Cell Death and Differentiation. 2020 Aug 15. doi: 10.1038/s41418-020-00608-8.
Boyan Huang#, Peiqiang Mu#, Yan Yu, Wenya Zhu, Tianqing Jiang, Rong Deng, Gongkan Feng, Jikai Wen, Xiaofeng Zhu*, Yiqun Deng* Inhibition of EZH2 and Activation of ERRγ Synergistically Suppresses Gastric Cancer by Inhibiting FOXM1 Signaling Pathway. Gastric Cancer. 2020 Jun 11. doi: 10.1007/s10120-020-01097-x.(# co-first author)
Shulin Tang, Yurong Zhao, Xirong He, Jiahui Zhu, Shuang Chen,Jikai Wen *, Yiqun Deng*, Identification of NOVA family proteins as novel β-catenin RNA-binding proteins that promote epithelial-mesenchymal transition. RNA Biology. 2020 Mar; DOI: 10.1080/15476286.2020.1734372
Shulin Tang, Shuang Chen, Boyan Huang, Jun Jiang, Jikai Wen, Yiqun Deng*. Deoxynivalenol induces inhibition of cell proliferation via the Wnt/beta-catenin signaling pathway. Biochemical Pharmacology. 2019 Aug; 166:12-22. (F1000★★)
Haoran Jiang, Jun Wu, Feiyong Zhang, Jikai Wen, Jun Jiang, Yiqun Deng*. The critical role of porcine cytochrome P450 3A46 in the bioactivation of aflatoxin B1. Biochemical Pharmacology. 2018 Oct; 156: 177-185.
Xiaoming Li, Peiqiang Mu, Han Qiao, Jikai Wen, Yiqun Deng*. JNK-AKT-NF-κB controls P-glycoprotein expression to attenuate the cytotoxicity of deoxynivalenol in mammalian cells. Biochemical Pharmacology. 2018 Oct; 156: 120-134.
Jun Jiang, Shulin Tang, Jianhong Xia, Jikai Wen, Shuang Chen, Xiaodong Shu, Michael S. Y. Huen, Yiqun Deng*. C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling. Oncogene. 2018 May; 37(22): 2992-3005.
Xin Liu, Jikai Wen, Ruohong Chen, Tingting Zhang, Jun Jiang, Yiqun Deng*. T-2 toxin induces the expression of porcine CYP3A22 via the upregulation of the transcription factor, NF-Y. Biochimica et Biophysica Acta-General Subjects. 2016 Oct; 1860(10): 2191-2201.
Linfeng Dong, Qingmei Chen, Xin Liu, Jikai Wen, Jun Jiang, Yiqun Deng*. Role of specificity protein 1, hepatocyte nuclear factor 1α, and pregnane x receptor in the basal and rifampicin-induced transcriptional regulation of porcine cytochrome P450 3A46. Drug Metabolism and Disposition. 2015 Oct; 43(10):1441-1449.
Qi Yang, Shulin Tang, Linfeng Dong, Qingmei Chen, Xin Liu, Jun Jiang, Yiqun Deng*. Transcriptional regulation of chicken cytochrome P450 2D49 (CYP2D49) basal expression by CCAAT/enhancer-binding protein α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α). FEBS Journal.2014 Mar; 281(5): 1379-1392.
Peiqiang Mu, Ming Xu, Lei Zhang, Kaixin Wu, Jun Wu, Jun Jiang, Qingmei Chen, Lijuan Wang, Xianqing Tang, Yiqun Deng*. Proteomic changes in chicken primary hepatocytes exposed to T-2 toxin are associated with oxidative stress and mitochondrial enhancement. Proteomics. 2013 Nov; 13(21): 3175-3188.
Jun Wu, Weiying Xu, Caihui Zhang, Qing Chang, Xianqing Tang, Kangbai Li, Yiqun Deng*. Trp266 determines the binding specificity of a porcine aflatoxin B1 aldehyde reductase for aflatoxin B1-dialdehyde. Biochemical Pharmacology. 2013 Nov; 86(9): 1357-1365.
Shirley M.H. Sy#, Jun Jiang#, Wai Sum O, Yiqun Deng*, Michael S.Y. Huen*. The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks. Nucleic Acids Research. 2013 Oct; 41(18): 8572-8580.(#co-first author)
Jie Chen, Wanjuan Feng, Jun Jiang, Yiqun Deng*, Michael S.Y. Huen*. Ring finger protein RNF169 antagonises the ubiquitin-dependent signaling cascade at sites of DNA damage. Journal of Biological Chemistry. 2012 Aug; 287(33): 27715-27722.
Jianshe Wang#, Jun Jiang#, Hongxia Zhang, Junping Wang, Hua Cai, Cheng Li, Kangbai Li, Jing Liu, Xuejiang Guo, Guangxun Zou, Dazhi Wang, Yiqun Deng*, Jiayin Dai*. Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes. Molecular & Cellular Proteomics. 2011 Sep; 10(9): M111.008748. (#co-first author)
Shirley M.H. Sy#, Jun Jiang#, Sui-sui Dong, Gabriel Tsz-Mei Lok, Jun Wu, Hua Cai, Enoch S.L. Yeung, Jun Huang, Junjie Chen, Yiqun Deng*, Michael S.Y. Huen*. Critical roles of ring finger protein RNF8 in replication stress responses. Journal of Biological Chemistry.2011 Jun; 286(25): 22355-22361.(#co-first author)
Invited review:
Jikai Wen, Peiqiang Mu, Yiqun Deng*. Mycotoxins: cytotoxicity and biotransformation in animal cells. Toxicology Research. 2016 Mar; 5(2): 377-387.
(The official journal of The British Toxicology Society and The Chinese Society of Toxicology)
Selected earlier publications:
Yiqun Deng, Jie Liu, Qi Zheng, Qunnu Li, Neville R. Kallenbach, Min Lu. A heterospecific leucine zipper tetramer. Chemistry & Biology. 2008 Sep;15(9): 908-919.(Current Journal Name: Cell Chemical Biology)
Yiqun Deng, Jie Liu, Qi Zheng, Wei Yong, Min Lu. Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein.Structure. 2006 May; 14(5): 889-899.
Yiqun Deng, Jie Liu, Qi Zheng, David Eliezer, Neville R. Kallenbach, Min Lu. Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat. Structure. 2006 Feb; 14(2): 247-255.
Jiayin Dai, Jie Liu, Yiqun Deng, Thomas M. Smith, Min Lu. Structure and protein design of a human platelet function inhibitor.Cell. 2004 Mar; 116(5): 649-659. (Featured Article)
1. 發(fā)明名稱：伊格爾茲氏菌Eggerthella sp. DII -9在降解嘔吐毒素中的應(yīng)用
發(fā)明人：鄧詣群、母培強(qiáng)、高小娟、陳慶梅、文繼開(kāi)
專利號(hào)：ZL 2016 1 0785036.4
授權(quán)公告日：2018年3月6日
2. 發(fā)明名稱：一株高效降解嘔吐毒素的伊格爾茲氏菌Eggerthella sp. DII-9
發(fā)明人：鄧詣群；高小娟；母培強(qiáng)；陳慶梅；文繼開(kāi)
專利號(hào)：ZL 2016 1 0785205.4
授權(quán)公告日：2017年7月11日
國(guó)家“萬(wàn)人計(jì)劃”科技創(chuàng)新領(lǐng)軍人才（2016年~）
科技部創(chuàng)新人才推進(jìn)計(jì)劃“中青年科技創(chuàng)新領(lǐng)軍人才”（2014年~）
廣東省高等學(xué)校特聘教授“珠江學(xué)者”（2009年~2014年）
教育部“新世紀(jì)優(yōu)秀人才支持計(jì)劃”（2008年~2011年）
榮譽(yù)獎(jiǎng)勵(lì)
全國(guó)師德標(biāo)兵、廣東省師德標(biāo)兵（2015年）
南粵優(yōu)秀教師（2012年）
第四屆中國(guó)僑界貢獻(xiàn)獎(jiǎng)（創(chuàng)新人才）（2012年）
教育部霍英東教育基金會(huì)第十三屆高等院校青年教師獎(jiǎng)（二等獎(jiǎng)）（2012年）
第十一屆廣東省丁穎科技獎(jiǎng)（2012年）
第十三屆廣東青年五四獎(jiǎng)?wù)拢?011年）
學(xué)術(shù)兼職
廣東省農(nóng)業(yè)生物蛋白質(zhì)功能與調(diào)控重點(diǎn)實(shí)驗(yàn)室 主任
中國(guó)生物化學(xué)與分子生物學(xué)會(huì) 理事
廣東省生物化學(xué)與分子生物學(xué)會(huì) 副理事長(zhǎng)
Society of Toxicology（美國(guó)毒理學(xué)會(huì)） Full Member
Frontiers in Pharmacology Guest Associate Editor
Curriculum Vitae
Name: Yiqun DENG
E-mail: yqdeng@scau.edu.cn
Address:
College of Life Sciences
South China Agricultural University
483 Wushan Road, Tianhe District
Guangzhou, Guangdong 510642
People's Republic of China
PRESENT ACADEMIC POSITION
2007.12 -
Professor of Biochemistry and Molecular Biology,
College of Life Sciences, South China Agricultural University
EDUCATION
Doctor,Biochemistry and Molecular Biology, Sun Yat-sen University, China, 2002
Master, Biochemistry and Molecular Biology, Zhongshan University of Medical Sciences, China, 1999
Bachelor, Clinical Medicine, Wannan Medical College, China, 1996
ACADEMIC QUALIFICATIONS
2007.7-2007.12
Instructor of Biochemistry
Weill Medical College of Cornell University, New York
2002.9-2007.6
Postdoctoral Fellow
Department of Biochemistry
Weill Medical College of Cornell University, New York
2000.8-2002.2
Visiting Scholar
Department of Biochemistry
Hong Kong University of Science & Technology, Hong Kong
RESEARCH INTEREST
The cytotoxicity of mycotoxins in animals.
The molecular mechanisms of metabolism for xenobiotics, especially mycotoxins.
The function, expression and regulation of key metabolic enzymes in animals, e.g. Cytochrome P450.
